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Institute of Metabolic Science

Metabolic Research Laboratories
 
Read more at: Professor Stephen O’Rahilly honoured with the Berthold Medal at the 68th German Congress of Endocrinology
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Professor Stephen O’Rahilly honoured with the Berthold Medal at the 68th German Congress of Endocrinology

24 March 2025

Professor Stephen O’Rahilly was recently awarded the Berthold Medal at the 68th German Congress of Endocrinology held in Baden Baden last week. The award took place as part of the Berthold Lecture on 20th March, in which Stephen gave an insight into his scientific work with his lecture on “ Adventures in Endocrinology...


Read more at: Dogs provide insight into obesity genetics
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Dogs provide insight into obesity genetics

6 March 2025

A study published in Science highlights the value of pet dogs as a model for understanding obesity in both humans and animals. This work was led by IMS-MRL and University of Cambridge Department of Physiology, Development and Neuroscience (PDN) researcher Dr Eleanor Raffan , along with PhD students Dr Natalie Wallis and Dr...


Read more at: Diabetes UK-funded study shows a reduced calorie diet in late pregnancy is safe and beneficial for women with gestational diabetes.
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Diabetes UK-funded study shows a reduced calorie diet in late pregnancy is safe and beneficial for women with gestational diabetes.

19 February 2025

We are delighted to have been part of this groundbreaking Diabetes UK-funded study into safety & benefits of a reduced calorie diet in late pregnancy in women with gestational diabetes. The Dietary Intervention in Gestational Diabetes (DiGest) trial involved researchers from the Universities of Cambridge and Leicester...


Read more at: Mapping the Human Hypothalamus: A Breakthrough in Understanding Metabolic Health
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Mapping the Human Hypothalamus: A Breakthrough in Understanding Metabolic Health

5 February 2025

Researchers at the IMS-MRL and MRC MDU in collaboration with a team at the Max Planck Institute for Metabolism Research in Cologne, have created the most detailed map to date of the human hypothalamus, a crucial brain region that regulates body weight, appetite, sleep, and stress. Published in Nature , this comprehensive...


Read more at: Brown adipose tissue is associated with reduced weight loss and risk of cancer cachexia

Brown adipose tissue is associated with reduced weight loss and risk of cancer cachexia

3 February 2025

Brown adipose tissue (BAT) is a special type of body fat that burns calories to generate heat and it has been studied for its potential to fight metabolic diseases like diabetes and heart disease. Recent research suggests it may also play a role in conditions involving extreme weight and muscle loss (e.g. cancer cachexia...


Read more at: Global Commission advocates changes to definition of obesity
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Global Commission advocates changes to definition of obesity

16 January 2025

A global Commission, published in The Lancet Diabetes & Endocrinology and endorsed by more than 75 medical organisations around the world, presents a new approach to diagnose obesity, based on measures of excess body fat in addition to body mass index (BMI), and objective signs and symptoms of ill health. The...


Read more at: Orthopedia regulates melanocortin 4 receptor transcription and energy homeostasis
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Orthopedia regulates melanocortin 4 receptor transcription and energy homeostasis

16 January 2025

Genetic studies have shown that the melanocortin 4 receptor (MC4R) plays a critical role in regulating food intake and body weight. However, surprisingly, little is known about how MC4R expression is regulated in the brain. In a study published in Science Translational Medicine , the Farooqi team collaborated with Chen Lui...


Read more at: Setmelanotide now licensed to treat children with genetic obesity from age 2
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Setmelanotide now licensed to treat children with genetic obesity from age 2

11 December 2024

The Farooqi team recently worked with colleagues across the world to complete a 12 month Phase 3 clinical trial of the Melanocortin 4 receptor agonist, Setmelanotide, in very young children (aged 2-5 years) with severe obesity due to genetic conditions which disrupt the function of the hypothalamic melanocortin pathway...


Read more at: Stephen O'Rahilly receives an award at international lipodystrophy symposium
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Stephen O'Rahilly receives an award at international lipodystrophy symposium

19 November 2024

Congratulations to Professor Stephen O’Rahilly who was presented with the Celia Carrión Pérez de Tudela Award in Lipodystrophy Research while at the AELIP 12th International Lipodystrophy Symposium in Santiago de Compostela, Spain earlier this month.


Read more at: Julia Ware awarded the 2024 Milo Keynes Prize for PhD Thesis
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Julia Ware awarded the 2024 Milo Keynes Prize for PhD Thesis

11 November 2024

Congratulations to Dr Julia Ware (Hovorka group) who has been awarded the Milo Keynes Prize for the academic year 2024, on submission of her PhD thesis - The impact of closed-loop insulin delivery on glucose control in children and young people with type 1 diabetes mellitus: Longer-term benefits across the paediatric age-...