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Institute of Metabolic Science

Metabolic Research Laboratories
 
Read more at: Apply now to study at the IMS-MRL
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Apply now to study at the IMS-MRL

5 November 2024

The Institute of Metabolic Science offers a world class environment for research in obesity, diabetes and cardiovascular disease. Training graduate students for a scientific career is a priority at the IMS-MRL. We have a mixture of both basic science students and clinical trainees and aim to provide everyone with a...


Read more at: Are weight loss jabs the solution to the obesity crisis?
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Are weight loss jabs the solution to the obesity crisis?

30 October 2024

Semaglutide-based weight loss drugs Wegovy and Ozempic - and others like them - are being hailed as ‘revolutionary’, with the potential to improve the lives of billions. The UK government has suggested they could boost the economy by helping obese people get back to work. But current estimates suggest almost two thirds of...


Read more at: Molecular mechanisms underlying glucose-dependent insulinotropic polypeptide secretion in human duodenal organoids
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Molecular mechanisms underlying glucose-dependent insulinotropic polypeptide secretion in human duodenal organoids

24 October 2024

Research from the Gribble-Reimann group has generated a new human organoid K cell model which enables transcriptomic and functional characterisation of nutrient-sensing pathways involved in human GIP (glucose-dependent insulinotropic polypeptide - an incretin hormone secreted by enteroendocrine K cells in the proximal...


Read more at: European Endocrine Society Award for Professor Krish Chatterjee

European Endocrine Society Award for Professor Krish Chatterjee

24 October 2024

Congratulations to Professor Krish Chatterjee on winning the prestigious European Hormone Medal from the European Society for Endocrinology - awarded to an international scientist who has made significant contributions to the field of basic or clinical endocrinology. This is the second major accolade for Krish this year...


Read more at: Congratulations to Professor Sue Ozanne - New Director and Head of Department
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Congratulations to Professor Sue Ozanne - New Director and Head of Department

8 October 2024

The IMS-MRL is delighted to announce that Professor Susan Ozanne PhD FMedSci has recently been appointed as its new Director. Sue will also take on the roles of Co-Director of the IMS and Head of the University Department of Clinical Biochemistry. Professor Stephen O’Rahilly MD FRS FMedSci will remain Director of the MRC...


Read more at: Liver fat – always the enemy?
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Liver fat – always the enemy?

25 September 2024

A study led by Sam Lockhart, Milan Muso , Steve O’Rahilly and others at the IMS-MRL, working with collaborators at the Universities of California, Newcastle and Leicester, has discovered that having some fat (specifically, a type of fat known as triglyceride) in liver cells may help the liver from being seriously damaged...


Read more at: MicroRNA-483: a missing link between the major growth factors IGF2 and IGF1
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MicroRNA-483: a missing link between the major growth factors IGF2 and IGF1

23 September 2024

Researchers from the Constancia group led by Ionel Sandovici and Denise Fernandez-Twinn, the Ozanne group and many other colleagues at the IMS-MRL, working in collaboration with the Universities of Cambridge, Glasgow, Montreal and Vienna, have unravelled a previously unrecognized link between Insulin-like growth factor 1 (...


Read more at: University of Cambridge, UCL and King’s researchers awarded UKRI funding for type 2 diabetes research

University of Cambridge, UCL and King’s researchers awarded UKRI funding for type 2 diabetes research

13 September 2024

Dr Daniel Fazakerley from the IMS-MRL, Dr Ivo Lieberam (King’s College London) and Professor Wenhui Song (University College London) are collaborating on a diabetes research project that has been awarded a total of £1.2m in funding from the UK Research and Innovation (UKRI)’s new interdisciplinary scheme. The project will...


Read more at: Cambridge-led study discovers cause of pregnancy sickness – and potential treatment
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Cambridge-led study discovers cause of pregnancy sickness – and potential treatment

13 December 2023

A collaborative study led by Professor Sir Stephen O’Rahilly , has shown why many women experience nausea and vomiting during pregnancy – and why some women, including the Duchess of Cambridge, become so sick they need to be admitted to hospital. The culprit is a hormone produced by the fetus – a protein known as GDF15...