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Institute of Metabolic Science

Metabolic Research Laboratories
 

Research focus

My role as Head of the Stable Isotope Laboratory is to oversee the running of the mass spectrometry laboratories and to provide methodological input for stable isotope studies. I oversee and contribute to methodological input, isotope dose provision, sample and data processing, modelling, data interpretation and report writing for stable isotope related studies.  

Background and experience

I completed my PhD at the University of Birmingham in 2008, and worked in postdoctoral positions at the University of Birmingham and Oxford Brookes University. In 2012, I joined the MRC Human Nutrition Research Unit, Cambridge, to develop my skills in the use of stable isotopes in metabolic research. I now work as Head of the Stable Isotope Laboratory at the University of Cambridge.  

Working at the IMS-MRL

Our laboratory has local, national and international collaborations with researchers who use stable isotopes for metabolic research. This includes the measurement of total energy expenditure using the reference method of doubly labelled water, body composition using deuterated water, breast milk intake using the dose-to-mother method and substrate kinetics. I have a long-standing collaboration with the NIHR Clinical Research Facility in Cambridge, investigating the relationships between growth, body composition and energy expenditure in healthy people and patient populations. 

Awards 

Co-I MRC New Investigator Award: Novel non-invasive assessment of de novo lipogenesis and its mechanistic role in human insulin resistance.  

Co-workers and collaborators

Daniel Griffiths 

Alison Sleigh 

Claire Connell 

Publications

Key publications: 

Venables, M.C., Roberts, C., Nicholson, S., Bates, B., Jones, K.S., Ashford, R., Hill, S., Farooq, A., Koulman, A., Wareham, N.J., Page, P. (2022) Data Resource Profile: United Kingdom National Diet and Nutrition Survey Rolling Programme (2008-2019). Int J Epidemiol 1-13. 

Gifford, R., Greeves, J., Wardle, S., O'Leary, T., Double, R., Venables, M., Boos, C., Langford, J., Woods, D., and Reynolds, R. (2021). Measuring the exercise component of energy availability during arduous training in women. Med Sci Sports Exerc. 53(4):860-868. 

Brage, S., Lindsay, T., Venables, M., Wijndaele, K., Westgate, K., Collins, D., Bluck, l., Wareham, N. and Page, P. (2020) Descriptive epidemiology of energy expenditure in the UK: Findings from the National Diet and Nutrition Survey 2008 – 2015.  Int J Epidemiol 49(3):1007-1021. 

Watson, L.P.E, Carr, K.S., Venables, M.C., Acerini, C., Moran, C., Murgatroyd, P.R. and Chatterjee, V.K. (2019) Quantifying energy expenditure in childhood: utility in managing paediatric metabolic disorders.  Am J Clin Nutr 110(5):1186-1191.  

Hulston, C. J., Venables, M. C., Mann, C., Philp, A., Baar, K., and Jeukendrup, A. E. (2010).  Training with low muscle glycogen increases fat oxidation during exercise. Med Sci Sports Exerc. 42(11):2046-2055 

Head of Stable Isotope Laboratory
Core Metabolomics and Lipidomics Laboratory (CMaLL)

Contact Details

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