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Institute of Metabolic Science

Metabolic Research Laboratories
 

Research focus

The aim of our group is to understand why some people gain weight more easily than others, and to identify new treatments for people with weight problems.  

Background and experience

I have always wanted to pursue a career in medical research. I initially did an undergraduate degree in Biochemistry at the University of Leeds before undertaking a PhD in Biomedical Sciences at the University of Dundee. After a short postdoctoral position, I decided to change directions and move into research co-ordination.  

Working at the IMS-MRL

Our research focus is to understand why some people gain weight more easily than others by looking for genes which are involved in regulating body weight. To do this we have recruited over 7500 participants with severe early-onset obesity from hospital settings to the Genetics of Obesity Study (GOOS) and over 3000 healthy thin participants from primary care for the Study into Thin and Lean Subjects (STILTS). As the Senior Research Co-ordinator, I had overall responsibility for recruitment to both studies. This includes ensuring that recruitment targets were met, samples were processed correctly and results were correctly documented.  

Our group is also currently running several clinical trials for treatments to control body weight and hunger in patients with genetic causes of obesity. I provide administrative support for these trials by arranging patient visits, ensuring that the data from patient visits is accurately recorded and working with external suppliers to ensure that patient visits run smoothly. More details about the study and our findings so far can be found on the websites for the GOOS (link https://www.goos.org.uk/home) and STILTS studies (link https://www.stilts.org.uk/). 

Publications

Key publications: 

Mendes de Oliveira E, Keogh JM, Talbot F, Henning E, Ahmed R, Perdikari A, Bounds R, Wasiluk N, Ayinampudi V, Barroso I, Mokrosiński J, Jyothish D, Lim S, Gupta S, Kershaw M, Matei C, Partha P, Randell T, McAulay A, Wilson LC, Cheetham T, Crowne EC, Clayton P, Farooqi IS. Obesity-Associated GNAS Mutations and the Melanocortin Pathway. N Engl J Med. 2021; 385(17):1581-1592. 

Brouwers B, de Oliveira EM, Marti-Solano M, Monteiro FBF, Laurin SA, Keogh JM, Henning E, Bounds R, Daly CA, Houston S, Ayinampudi V, Wasiluk N, Clarke D, Plouffe B, Bouvier M, Babu MM, Farooqi IS, Mokrosiński J. Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation. Cell Rep. 2021; 34(12):108862.  

Marenne G, Hendricks AE, Perdikari A, Bounds R, Payne F, Keogh JM, Lelliott CJ, Henning E, Pathan S, Ashford S, Bochukova EG, Mistry V, Daly A, Hayward C; INTERVAL, UK10K Consortium, Wareham NJ, O'Rahilly S, Langenberg C, Wheeler E, Zeggini E, Farooqi IS, Barroso I. Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription. Cell Metab. 2020 Jun 2;31(6):1107-1119.e12.  

Riveros-McKay F, Mistry V, Bounds R, Hendricks A, Keogh JM, Thomas H, Henning E, Corbin LJ; Understanding Society Scientific Group, O'Rahilly S, Zeggini E, Wheeler E, Barroso I, Farooqi IS. Genetic architecture of human thinness compared to severe obesity. PLoS Genet. 2019 Jan 24;15(1):e1007603.  

Senior Research Co-ordinator
Farooqi Group

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