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Institute of Metabolic Science

Metabolic Research Laboratories
 

Research focus

I oversee the scientific and operational management of the TVP group’s murine metabolic and cardiometabolic phenotyping programmes. These cover two key areas: Mouse physiology and metabolic phenotyping in the context of obesity and metabolic complications, and human stem cell research. 

Background and experience

I studied for a BSc in Biochemistry at Cardiff University, then worked at the Wellcome Trust Sanger Institute (WSI), and the University of NSW (UNSW) in Australia. I have been employed as part of Professor Toni Vidal-Puig’s group working at the Wellcome Trust-MRC Institute of Metabolic Science (IMS) since 2003. I am a certified project manager (Prince2) and holder of two PPL project licences. 

Working at the IMS-MRL

My current role includes the ongoing assessment and optimisation of the teams’ resources required to carry out our research according to appropriate timelines and defined budgetary targets. This includes managing our people, our finances and our technologies in a coordinated way. With oversight of >10 scientific researchers, my role has been to continuously review and improve both the design and performance of all areas of our programme, including scientific direction, management and control, compliance, supervision and training, reporting and communication. 

Through the use and dissemination of scientific evidence, appropriate metrics, key performance indicators, knowledge and experience, I am involved in the identification and mitigation of process failures in order to improve workflow and productivity, ensure incorporation of best practices, maximize research quality, and ultimately oversee and increase capabilities that contribute towards the scientific output from the team. 

Key scientific interests in the context of obesity, diabetes, and non-alcoholic fatty liver disease: 

1) Characterisation of murine metabolic phenotypes 

2) Adipose tissue biology 

3) Mitochondrial dysfunction 

Publications

Key publications: 

Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance. Pellegrinelli V, Rodriguez-Cuenca S, Rouault C, Figueroa-Juarez E, Schilbert H, Virtue S, Moreno-Navarrete JM, Bidault G, Vázquez-Borrego MC, Dias AR, Pucker B, Dale M, Campbell M, Carobbio S, Lin YH, Vacca M, Aron-Wisnewsky J, Mora S, Masiero MM, Emmanouilidou A, Mukhopadhyay S, Dougan G, den Hoed M, Loos RJF, Fernández-Real JM, Chiarugi D, Clément K, Vidal-Puig A. Nat Metab. 2022 

Allostatic hypermetabolic response in PGC1α/β heterozygote mouse despite mitochondrial defects.Rodriguez-Cuenca S, Lelliot CJ, Campbell M, Peddinti G, Martinez-Uña M, Ingvorsen C, Dias AR, Relat J, Mora S, Hyötyläinen T, Zorzano A, Orešič M, Bjursell M, Bohlooly-Y M, Lindén D, Vidal-Puig A. FASEB J. 2021 

Regulation of adipogenic differentiation and adipose tissue inflammation by interferon regulatory factor 3. Tang P, Virtue S, Goie JYG, Png CW, Guo J, Li Y, Jiao H, Chua YL, Campbell M, Moreno-Navarrete JM, Shabbir A, Fernández-Real JM, Gasser S, Kemeny DM, Yang H, Vidal-Puig A, Zhang Y. Cell Death Differ. 2021 

Scientific and Operational Excellence Manager
TVP Lab

Contact Details

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