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Institute of Metabolic Science

Metabolic Research Laboratories
 

Research focus

My main research interest focuses on neuroendocrinology, in particular the brain circuits controlling energy homeostasis and reproduction, and how they interconnect in physiological and pathophysiological conditions.  

Background and experience

I became interested in neuroscience after my Biological Sciences bachelor’s degree at the university or Rome La Sapienza in Italy, this led me to get a master in neurobiology at the University of Turin where I worked on adult neurogenesis in the olfactory bulb. My interests then narrowed to neuroendocrinology during my PhD in France (University of Lille) where I studied the neuronal circuits controlling reproductive functions in physiological and pathophysiological conditions like polycystic ovary syndrome (PCOS).  

Working at the IMS-MRL

I have worked at the IMS-MRL for several years as a research associate. During this time, I have expanded and consolidated my skills in omics techniques and energy homeostasis in rodents.  

My current projects cover the study of changes and adaptations of neuroendocrine axes in response to stressful stimuli like sickness or diseases using both in vivo models and molecular biology.  

Publications

Key publications: 

Lam BYH*, Williamson A*, Finer S*, Day FR, Tadross JA, Gonçalves Soares A, Wade K, Sweeney P, Bedenbaugh MN, Porter DT, Melvin A, Ellacott KLJ, Lippert RN, Buller S, Rosmaninho-Salgado J, Dowsett GKC, Ridley KE, Xu Z, Cimino I, Rimmington D, Rainbow K, Duckett K, Holmqvist S, Khan A, Dai X, Bochukova EG, Genes & Health Research Team, Trembath RC, Martin HC, Coll AP, Rowitch DH, Wareham NJ, van Heel DA, Timpson N, Simerly RB, Ong KK, Cone, RD, Langenberg C*, Perry JRB*, Yeo GS*, O’Rahilly S. MC3R links nutritional state to childhood growth and the timing of puberty. Nature. 2021 https://doi.org/10.1038/s41586-021-04088-9  

Cimino I, Rimmington D, Tung YCL, Lawler K, Larraufie P, Kay RR, Virtue S, Lam BYH, Fagnocchi L, Ma M, Saudek V, Zvetkova I, Vidal-Puig A, Yeo GSH, Farooqi IS, Pospsiilik A, Gribble FM, Reimann F, O’Rahilly S, Coll AP. Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity. Sci Rep. 2021 Sep 2;11(1):17571. https://doi.org/10.1038/oby.2009.361.  

Cimino I, Kim H, Tung YCL., Pedersen K, Debra Rimmington, John A. Tadross, Sara N. Kohnke, Ana Neves- Costa, Barros A, Joaquim S, Bennett D, Melvin A, Lockhart SM, Rostron AJ, Scott J, Liu H, Burling K, Barker P, Clatworthy MR, E-C. Lee, Simpson AJ, Yeo GSH, Moita LF, Bence KK, Beck Jørgensen S, Coll AP, Breen DM and O’Rahilly S. Activation of the Hypothalamic-Pituitary-Adrenal axis by exogenous and endogenous GDF15. PNAS July 6, 2021, 118 (27) e2106868118; https://doi.org/10.1073/pnas.2106868118.  

Liang ZS, Cimino I, Yalcin B, Raghupathy N, Vancollie VE, Ibarra-Soria X, Firth HV, Rimmington D, Farooqi IS, Lelliott CJ, Munger SC, O'Rahilly S, Ferguson-Smith AC, Coll AP, Logan DW. Trappc9 deficiency causes parent-of-origin dependent microcephaly and obesity. PLoS Genet. 2020 Sep 2;16(9). https://doi.org/10.1371/journal.pgen.1008916.  

Lam BYH, Cimino I, Polex-Wolf J, Nicole Kohnke S, Rimmington D, Iyemere V, Heeley N, Cossetti C, Schulte R, Saraiva LR, Logan DW, Blouet C, O'Rahilly S, Coll AP, Yeo GSH. Heterogeneity of hypothalamic pro- opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing. Mol Metab. 2017 Mar 1;6(5):383-392. https://doi.org/10.1016/j.molmet.2017.02.007.  

Research Associate
Coll group

Contact Details

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