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Institute of Metabolic Science

Metabolic Research Laboratories
 

Research focus

The broader aim of my scientific research is to study aspects of deregulation in cellular events that lead to metabolic disorders.

Background and experience

My Ph.D thesis focussed on identifying a mechanistic pathway macrophages employ to utilise stored triglycerides. During this time, I had developed scientific and technical skills pertaining to addressing questions related with cell biology and lipid biochemistry.

Working at the IMS-MRL

The overall aim of my current research is to identify aberrations in cellular events that lead to impaired GLUT4 translocation and thereby insulin resistance. I use a variety of cell, molecular and biochemical techniques to study these aspects.

Publications

Key publications: 

Menon D, Bhapkar A, Manchandia B, Charak G, Rathore S, Jha R.M, Nahak A, Mondal M, Omrane M, Bhaskar A.K , Thukral L,Thiam A.R, Gandotra S; ARL8B mediates lipid droplet turnover via contact with both LDs and lysosomes, Cell Reports (2023): 42 (10).

Dawa S, Menon D, Arumugam P, Bhaskar A.K, Mondal M, Rao V and Gandotra S; Inhibition of granuloma triglyceride synthesis imparts control of Mycobacterium tuberculosis through curtailed
inflammatory responses; Frontiers in Immunology (2021): 12.

Menon D, Pinto S.K, Nandy A, Jaisinghani N, Kutum R, Dash D, Prasad T.S.K, Gandotra S; Quantitative lipid droplet proteomics reveals Mycoabcterium tuberculosis induced alterations in macrophage response to infection; ACS Infectious Diseases (2019): (5)559-569.

Mishra R, Menon D, Gandotra S and Singh Y; Tuning the Mycobacterium tuberculosis alternative sigma factor SigF through the multidomain regulator Rv1364c and osmosensory kinase, protein kinase D; Journal of Bacteriology (2019): 201 (7).

Jaisinghani N, Dawa S, Singh K, Nandy A, Menon D, Bhandari P.D, Khare G, Tyagi A and Gandotra S; Necrosis Driven Triglyceride synthesis primes macrophages for inflammation
during Mycobacterium tuberculosis infection; Frontiers in Immunology (2018): 1490 (9).

Research Associate
Fazakerley Group

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