skip to content

Institute of Metabolic Science

Metabolic Research Laboratories
 

Research Interests 

My research aims to investigate how disorders of energy balance and body composition can result from disruption of the pathways that control how we eat, how we metabolise fuel and how we store energy in tissues. The basis of these studies comes primarily from studies of human disease, including rare genetic forms of obesity and larger population-based studies. 

In collaboration with colleagues in the IMS (O’Rahilly,Yeo) my work aims to gain a more mechanistic understanding of pathways highlighted by these human studies. Our current understanding of the central control of appetite has relied heavily upon mouse models and I combine murine genetics and whole animal physiological studies to address these issues. 

A key themes emerging from this work has been that neurohormonal pathways are crucial in determining appetitive behaviour and body composition. These same pathways are highly likely to be relevant to other disorders of body composition and with colleagues in Team CANCAN (https://teamcancan.com) funded through the Cancer Grand Challenges initiative, I am part of a multidisciplinary team working together to understand the mechanisms behind cancer cachexia. 


Group Members 

Irene Cimino (Research Associate) (Coll, O’Rahilly Yeo) - ic326 at medschl.cam.ac.uk 

Kara Rainbow (Research Assistant) (Coll, O’Rahilly, Yeo)  - kh271 at medschl.cam.ac.uk  

Matteo Mastantuoni (Research Assistant) (Coll, O’Rahilly) - mm2651 at medschl.cam.ac.uk  

Loraine Tung (Research Associate) (Coll, O’Rahilly, Yeo) - lyct2 at medschl.cam.ac.uk  

Joanne Shen (Research Associate) (Coll, O’Rahilly) - js2901 at medschl.cam.ac.uk 

Xue-Li Wong (Ph.D student) (with O’Rahilly) - xlw23 at medschl.cam.ac.uk 

Dr Sui Lei Yin (Clinical Fellow) 


Funding 

Medical Research Council  

CRUK and National Cancer Institute (US) 

University Associate Professor
Department of Clinical Biochemistry
photo of tony coll

Contact Details

Email address: