The Institute of Metabolic Science-Metabolic Research Laboratories (IMS-MRL) and its embedded Medical Research Council (MRC) Metabolic Diseases Unit investigate the mechanisms through which metabolic health is maintained and how this is disturbed in disease. We seek to use that knowledge to aid better treatment and prevention of obesity, Type 2 diabetes and related endocrine and metabolic diseases.
IMS-MRL research groups encompass skills in genetics, cell biology, cell signalling, neuroendocrinology, bioenergetics, human and animal physiology, experimental medicine and clinical trials.
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5 November 2024
The Institute of Metabolic Science offers a world class environment for research in obesity, diabetes and cardiovascular disease. Training graduate students for a scientific career is a priority at the IMS-MRL. We have a mixture of both basic science students and clinical trainees and aim to provide everyone with a...
Are weight loss jabs the solution to the obesity crisis?
30 October 2024
Semaglutide-based weight loss drugs Wegovy and Ozempic - and others like them - are being hailed as ‘revolutionary’, with the potential to improve the lives of billions. The UK government has suggested they could boost the economy by helping obese people get back to work. But current estimates suggest almost two thirds of...
24 October 2024
Research from the Gribble-Reimann group has generated a new human organoid K cell model which enables transcriptomic and functional characterisation of nutrient-sensing pathways involved in human GIP (glucose-dependent insulinotropic polypeptide - an incretin hormone secreted by enteroendocrine K cells in the proximal...
