skip to content
Home

Institute of Metabolic Science

Metabolic Research Laboratories
 

Lu Long

Research focus

I work in the Disease Model Core (DMC) where I am responsible for developing new techniques, new methods and new technologies to support research in the IMS-MRL. 

Background and experience

I did my PhD training in hypoxia-induced pulmonary hypertension in rodent models at Imperial College London, based at the Hammersmith Campus. I had been working in the same field for more than 20 years before I joined the DMC in 2019.  

Working at the IMS-MRL

My day-to-day work includes performing routine and specialist procedures and metabolic experiments to generate data for the IMS-MRL researchers and their programmes. I also independently design, develop and implement new experimental methodologies which can be used to support cutting-edge research within our department.   

Publications

Key publications: 

Long L, Yang X, Southwood M, Moore S, Crosby A, Upton PD, Dunmore BJ, Morrell NW. Targeting translational read-through of premature termination mutations in BMPR2 with PTC124 for pulmonary arterial hypertension. Pulm Circ. 2020 Jul 20;10(3):2045894020935783.  

 Long L, Ormiston ML, Yang X, Southwood M, Gräf S, Machado RD, Mueller M, Kinzel B, Yung LM, Wilkinson JM, Moore SD, Drake KM, Aldred MA, Yu PB, Upton PD, Morrell NW. Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. Nat Med. 2015;21(7):777-85.  

Long L, MacLean MR, Jeffery TK, Morecroft I, Yang X, Rudarakanchana N, Southwood M, James V, Trembath RC, Morrell NW. Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice. Circ Res. 2006;98(6):818-27.  

Long L, Yang X, Southwood M, Lu J, Marciniak SJ, Dunmore BJ, Morrell NW. Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation. Circ Res. 2013;112(8):1159-70. 

Long L, Crosby A, Yang X, Southwood M, Upton PD, Kim DK, Morrell NW. Altered bone morphogenetic protein and transforming growth factor-beta signaling in rat models of pulmonary hypertension: potential for activin receptor-like kinase-5 inhibition in prevention and progression of disease. Circulation. 2009;119(4):566-76.  

Senior Technologist
Disease Model Core

Contact Details

Email address: 
ll254@medschl.cam.ac.uk
Collaborator profiles: 
Dr Clemence Blouet
Classifications: 
Core Facilities

Study at Cambridge

About the University

Research at Cambridge